MovDisordV3, Main, Exploration, bibRecord, 004598

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Identifieur interne : 004598 ( Main/Exploration ); précédent : 004597; suivant : 004599

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Auteurs : Joseph O'Neill [États-Unis] ; Norbert Schuff [États-Unis] ; William J. Jr Marks [États-Unis] ; Robert Feiwell [États-Unis] ; Michael J. Aminoff [États-Unis] ; Michael W. Weiner [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0583402

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Imagerie RMN, Spectrométrie RMN, Analyse quantitative, Encéphale, Exploration, Homme.
Wicri :
- topic : Analyse quantitative, Homme.

English descriptors

KwdEn :
- Brain (vertebrata), Exploration, Human, NMR spectrometry, Nuclear magnetic resonance imaging, Parkinson disease, Quantitative analysis.

Abstract

Magnetic resonance imaging (MRI) and ¹H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current ¹H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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H magnetic resonance spectroscopy and MRI of Parkinson's disease</title>
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H magnetic resonance spectroscopy and MRI of Parkinson's disease</title>
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<front><div type="abstract" xml:lang="en">Magnetic resonance imaging (MRI) and <sup>1</sup>
H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current <sup>1</sup>
H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.</div>
</front>
</TEI>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="O Neill, Joseph" sort="O Neill, Joseph" uniqKey="O Neill J" first="Joseph" last="O'Neill">Joseph O'Neill</name>
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<name sortKey="Aminoff, Michael J" sort="Aminoff, Michael J" uniqKey="Aminoff M" first="Michael J." last="Aminoff">Michael J. Aminoff</name>
<name sortKey="Aminoff, Michael J" sort="Aminoff, Michael J" uniqKey="Aminoff M" first="Michael J." last="Aminoff">Michael J. Aminoff</name>
<name sortKey="Feiwell, Robert" sort="Feiwell, Robert" uniqKey="Feiwell R" first="Robert" last="Feiwell">Robert Feiwell</name>
<name sortKey="Marks, William J Jr" sort="Marks, William J Jr" uniqKey="Marks W" first="William J. Jr" last="Marks">William J. Jr Marks</name>
<name sortKey="Marks, William J Jr" sort="Marks, William J Jr" uniqKey="Marks W" first="William J. Jr" last="Marks">William J. Jr Marks</name>
<name sortKey="O Neill, Joseph" sort="O Neill, Joseph" uniqKey="O Neill J" first="Joseph" last="O'Neill">Joseph O'Neill</name>
<name sortKey="Schuff, Norbert" sort="Schuff, Norbert" uniqKey="Schuff N" first="Norbert" last="Schuff">Norbert Schuff</name>
<name sortKey="Schuff, Norbert" sort="Schuff, Norbert" uniqKey="Schuff N" first="Norbert" last="Schuff">Norbert Schuff</name>
<name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name>
<name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri